Qi Gao Selected Research

2- (2- (3,5- difluorophenyl)- 2- hydroxyacetamido)- N- (3- methyl- 4- oxo- 4,5- dihydro- 3H- benzo(d)(1,2)diazepin- 5- yl)propanamide

7/2007

Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease.

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Qi Gao Research Topics

Disease

37	Neoplasms (Cancer) 01/2022 - 08/2009
29	Infections 01/2022 - 06/2011
17	Malaria 07/2017 - 12/2008
16	Stroke (Strokes) 12/2021 - 02/2005
14	Inflammation (Inflammations) 01/2022 - 01/2012
11	Cognitive Dysfunction 01/2022 - 10/2012
9	Frailty 01/2022 - 01/2017
9	Toxoplasmosis 01/2018 - 06/2011
8	Cardiovascular Diseases (Cardiovascular Disease) 10/2021 - 03/2016
7	Hepatocellular Carcinoma (Hepatoma) 05/2019 - 01/2012
6	Body Weight (Weight, Body) 06/2022 - 07/2009
6	Hypoxia (Hypoxemia) 01/2022 - 09/2015
6	COVID-19 01/2022 - 01/2020
6	Atherosclerosis 10/2020 - 11/2010
5	Hypertension (High Blood Pressure) 06/2022 - 01/2016
5	Pain (Aches) 01/2022 - 01/2019
5	Myocardial Infarction 12/2021 - 11/2016
5	Neoplasm Metastasis (Metastasis) 07/2021 - 01/2018
5	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 12/2006
4	Heart Failure 06/2022 - 11/2016
4	Wounds and Injuries (Trauma) 01/2021 - 09/2015
4	Cysts 10/2020 - 06/2011
4	Carcinogenesis 10/2018 - 11/2016
3	Chronic Pain 11/2022 - 01/2019
3	Acute Kidney Injury (Acute Renal Failure) 06/2022 - 01/2021
3	Migraine Disorders (Migraine) 01/2022 - 11/2020
3	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 01/2021
3	Vivax Malaria 01/2022 - 06/2010
3	Sarcopenia 01/2022 - 12/2018
3	Obesity 12/2021 - 05/2016
3	Osteonecrosis (Kienbock's Disease) 10/2021 - 01/2021
3	Pancreatic Neoplasms (Pancreatic Cancer) 07/2021 - 01/2015
3	Hemorrhage 04/2021 - 11/2013
3	Necrosis 01/2021 - 03/2013
3	Fibrosis (Cirrhosis) 01/2021 - 11/2012
3	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 03/2006
3	Residual Neoplasm 01/2021 - 01/2018
3	Chronic Renal Insufficiency 01/2021 - 12/2019
3	Echinococcosis (Hydatid Cysts) 10/2020 - 10/2018
3	Type 2 Diabetes Mellitus (MODY) 07/2020 - 05/2017
3	Breast Neoplasms (Breast Cancer) 01/2020 - 07/2011
3	Atrial Fibrillation 01/2019 - 01/2016
3	Stomach Neoplasms (Stomach Cancer) 10/2018 - 10/2013
3	Dementia (Dementias) 01/2018 - 11/2013
3	Atherosclerotic Plaque (Atheroma) 01/2016 - 11/2010
3	Clonorchiasis 08/2012 - 04/2011
2	Chylous Ascites 05/2022 - 04/2020
2	Sickle Cell Anemia (Hemoglobin S Disease) 03/2022 - 01/2022
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2022 - 01/2021

Drug/Important Bio-Agent (IBA)

28	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2007
13	VaccinesIBA 01/2022 - 12/2008
11	CytokinesIBA 01/2022 - 01/2012
9	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2012
8	LipidsIBA 12/2021 - 10/2012
8	Apolipoproteins E (ApoE)IBA 11/2020 - 11/2010
7	MicroRNAs (MicroRNA)IBA 07/2021 - 08/2013
6	Pharmaceutical PreparationsIBA 06/2022 - 04/2015
6	EnzymesIBA 01/2022 - 08/2012
6	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 06/2011
6	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 03/2011
6	AntigensIBA 01/2021 - 12/2012
6	Interleukin-17 (Interleukin 17)IBA 12/2020 - 11/2010
5	AntibodiesIBA 01/2022 - 03/2014
5	ApolipoproteinsIBA 11/2020 - 07/2013
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019 - 10/2007
4	Cisplatin (Platino)FDA LinkGeneric 06/2022 - 10/2013
4	SuspensionsIBA 05/2022 - 06/2011
4	Immunoglobulin G (IgG)IBA 01/2022 - 04/2010
4	Messenger RNA (mRNA)IBA 10/2021 - 10/2013
4	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021 - 01/2016
4	InterleukinsIBA 01/2021 - 01/2018
4	Antiviral Agents (Antivirals)IBA 12/2020 - 01/2017
4	CholesterolIBA 12/2020 - 08/2017
4	AlbuminsIBA 01/2018 - 01/2015
4	Antimalarials (Antimalarial Agents)IBA 06/2015 - 06/2010
3	RNA (Ribonucleic Acid)IBA 12/2022 - 09/2014
3	Therapeutic UsesIBA 01/2022 - 01/2015
3	Peptides (Polypeptides)IBA 01/2022 - 09/2017
3	Opioid Analgesics (Opioids)IBA 01/2022 - 01/2019
3	Transcription Factors (Transcription Factor)IBA 01/2022 - 10/2020
3	salicylhydroxamic acid (SHAM)IBA 01/2022 - 07/2012
3	Complement System Proteins (Complement)IBA 05/2021 - 10/2016
3	Interleukin-4 (Interleukin 4)IBA 01/2021 - 02/2012
3	Small Interfering RNA (siRNA)IBA 01/2021 - 07/2011
3	Long Noncoding RNAIBA 01/2021 - 10/2018
3	Amino Acids FDA Link 01/2020 - 08/2017
3	A-Form DNA (A-DNA)IBA 01/2018 - 01/2017
3	Biological ProductsIBA 11/2016 - 03/2006
2	CarbonIBA 05/2022 - 04/2020
2	high fluorescent intermediate IIIBA 01/2022 - 01/2022
2	HomocysteineIBA 01/2022 - 09/2021
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 01/2021

Therapy/Procedure

32	Therapeutics 12/2022 - 01/2007
7	Drug Therapy (Chemotherapy) 06/2022 - 10/2013
3	Moxibustion 01/2022 - 11/2020
3	Aftercare (After-Treatment) 01/2022 - 02/2005
3	Activities of Daily Living (ADL) 01/2022 - 03/2017
3	Decompression 10/2021 - 01/2021
3	Immunotherapy 12/2020 - 05/2019
3	Blood Transfusion (Blood Transfusions) 10/2015 - 10/2014